Patna: An indigenous vaccine for dengue, developed under the Indian Council of Medical Research (ICMR), is now being tested on healthy volunteers in Patna, marking a significant step towards India’s first homegrown protection against the viral disease.
The Rajendra Memorial Research Institute of Medical Sciences (RMRIMS) in Agamkuan has begun administering the vaccine to adults aged 18–60, as part of a nationwide Phase III trial being conducted at 19 centres. Scientists at the institute say they are working round the clock to meet the trial timelines.
At present, there is no specific drug for dengue; treatment relies on supportive care, including paracetamol and platelet transfusions when required.
Dr Krishna Pandey, director of RMRIMS, said the vaccine candidate — developed by Panacea Biotech in New Delhi under ICMR’s guidance — will be tested on 400 healthy volunteers at the Patna centre. “Once the two-year trial concludes and results are analysed, the vaccine will be ready for wider use,” he said.
Kala-azar and malaria research underway
Alongside the dengue trial, RMRIMS is also running clinical trials for a new oral drug for Kala-azar. A tablet named LXE 408 is being tested on 105 patients, with results expected in six months. An earlier capsule-based treatment has already been developed, Dr Pandey said.
He added that Kala-azar has been largely controlled in India, including Bihar. Patients continue to be monitored for three years in Bihar, Jharkhand, Uttar Pradesh and West Bengal. “If the programme succeeds by the end of 2026, India will receive WHO certification declaring the country Kala-azar-free,” he said.
The institute is also investigating the presence of malaria among migrant labourers. Samples collected from 600 workers engaged in construction work in Patna and Muzaffarpur have been tested so far, with around 10 cases returning positive. The study will eventually cover 2,000 labourers.
RMRIMS marked its 62nd foundation day on Wednesday, with scientists highlighting the institute’s expanding role in infectious disease research.
